The Inhibitory Effect of Selenomethionine and Sodium Selenite on a Human Cholangiocyte MMNK1 Cell Line

Cholangiocarcinoma (CCA) is a malignant tumor arisen from bile duct epithelial cells. Liver fluke (Opisthorchis viverrini) infection is considered as a main cause of CCA in Northeast Thailand. Low Se intake has been found to be associated with the high risk of several cancers. The chemotherapeutic and chemopreventive potentials of several selenium compounds have been studied and proved in many cancers, which draw our attention on the selenium supplements on CCA. This study aimed to demonstrate the inhibitory effect of 2 selenium compounds, selenomethionine (SeMet) and sodium selenite, on cell viability and migration of a human immortal cholangiocyte MMNK1 cell line using sulforhodamine B assay and wound healing assay, respectively. Our results showed that selenium compounds suppressed the cell viability of MMNK1 but they did not affect cell migration. Our data suggest for the role of selenium compounds in CCA chemoprevention.